Piracetam (chemical name is 2-oxo-1-pyrrolidine acetamide) is a nootropic. Piracetam was developed by Romanian chemist, Corneliu E. Giurgea in 1964. It shares the same 2-oxo-pyrrolidone base structure with 2-oxo-pyrrolidine carboxylic acid (pyroglutamate). Piracetam is a cyclic derivative of GABA but its mechanism of action is not fully understood. It is one of the group of racetams. Piracetam was the first racetam developed and has a long history of use in the medical field and is is prescribed by doctors for some conditions, mainly myoclonus, but is used off-label for a much wider range of applications like dyslexia, alzheimer or elderly dementia.
Using this compound benefits the brain in a non-specific manner not favoring any single aspect of cognition, but all of them. Cognitive enhancing properties of Piracetam in healthy persons are understudied and fairly weak (but positive) and sometimes hard to notice. Effects are more visible after long-term use. It takes about two weeks for piracetam’s effects to become statistically significant. Piracetam is not toxic and relatively safe, appears to preserve health in a non-specific and weak manner, and may be a useful longevity agent. Is recommended by many healthcare professionals and health organizations, such as the Life Extension Foundation and is approved and used since 1970’s worldwide (Europe, Asia, and South American).
- Enhances brain metabolism – increasing glucose utilization, blood & oxygen flow.
- Boosts mental energy and cerebral circulation.
- Supports healthy neuron communication and structure.
- Supports cognitive receptors – strengthens neurotransmitter receptors involved in memory and neuroprotection.
- Increases memory and improves learning – stimulates the neurons involved in information processing, attention, cortical/behavioral arousal, learning and memory.
- Supports healthy blood flow – improves vasodilation and inhibits platelet aggregation.
- Increases focus and heightens sensory function.
- Reduces anxiety and depression.
- Has a significant antioxidant effect – reduces free radicals in the brain that causes oxidative stress (can be a cause of Alzheimer’s and dementia).
- Reduces brain trauma.
- 2-6 grams daily for adults.
- Optimal effective dose appears to be 1600mg of piracetam taken thrice a day in divided doses to total 4800mg.
Side effects of higher dosages: headaches, nausea, fatigue, insomnia, gastrointestinal issues and depression.
Often taken with: Choline, ALCAR, natural GABA antagonists or natural adrenal support
Synergistics: creatine, uridine, MCT Oil, Lions Mane Mushroom